Adhesion receptors and cytokine profiles in controlled tourniquet ischaemia in the upper extremity

被引：12

作者：

Germann, G ^{[1
]}

Drücke, D ^{[1
]}

Steinau, HU ^{[1
]}

机构：

[1] BG Trauma Ctr, Burn Ctr, Dept Plast & Hand Surg, D-67071 Ludwigshafen, Germany

来源：

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME | 1997年 / 22B卷 / 06期

关键词：

D O I：

10.1016/S0266-7681(97)80447-0

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Adhesion mechanisms mediated by cytokines have been recognized to play a crucial role in ischaemia-reperfusion mechanisms. Although this phenomenon has been well investigated in organ transplantation, little data is available from upper extremity surgery. Profiles of adhesion molecules (CD11/CD18), key cytokines (TNF-alpha and IL-1), CD4+ and CD8+ lymphocytes, and polymorphonuclear neutrophils were investigated following controlled tourniquet ischaemia of the upper extremity for elective hand surgery. Data suggest that relatively short periods of ischaemia activate a mediator cascade and cell-cell interactions that may be associated with adverse pathophysiological effects on peripheral tissues after prolonged ischaemia.

引用

页码：778 / 782

页数：5

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