High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation

被引：30

作者：

Chuang, SS

Lee, CA

Hamoudi, RA

Liu, HX

Lee, PS

Ye, HT

Diss, TC

Dogan, A

Isaacson, PG

Du, MQ

机构：

[1] UCL, Dept Histopathol, London WC1E 6JJ, England

[2] Chi Mei Med Ctr, Dept Internal Med, Dept Pathol, Tainan, Taiwan

[3] Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol, Tainan, Taiwan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 120卷 / 01期

关键词：

high-grade transformation; MALT lymphoma; p53; RT-PCR; t(11; 18);

D O I：

10.1046/j.1365-2141.2003.04035.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients.Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

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页码：97 / 100

页数：4

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