The mevalonate-independent methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis, including carotenoids

被引:32
作者
Rohmer, M [1 ]
机构
[1] Univ Strasbourg, CNRS, Inst Univ France, Inst Le Bel, F-67070 Strasbourg, France
关键词
D O I
10.1351/pac199971122279
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A mevalonate-independent route to isopentenyl diphosphate (IPP), the universal precursor of isoprenoids, is present in many bacteria, in some unicellular green algae and in the plant plastids. All essential isoprenoids related to photosynthesis, including the carotenoids, are synthesized via this alternative metabolic route. IPP is formed from pyruvate and glyceraldehyde 3-phosphate via 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate. Later steps are still poorly known, although extensive data on the origin of the hydrogen atoms of IPP are now available.
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页码:2279 / 2284
页数:6
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