Molecular definitions of autophagy and related processes

被引：1781

作者：

Galluzzi, Lorenzo ^{[1
,2
]}

Baehrecke, Eric H. ^{[3
]}

Ballabio, Andrea ^{[4
,5
,6
,7
]}

Boya, Patricia ^{[8
]}

Pedro, Jose Manuel Bravo-San ^{[2
,9
,10
,11
,12
]}

Cecconi, Francesco ^{[13
,14
,15
]}

Choi, Augustine M. ^{[16
]}

Chu, Charleen T. ^{[17
]}

Codogno, Patrice ^{[2
,18
,19
,20
]}

Isabel Colombo, Maria ^{[21
,22
]}

Maria Cuervo, Ana ^{[23
]}

Debnath, Jayanta ^{[24
]}

Deretic, Vojo ^{[25
]}

Dikic, Ivan ^{[26
,27
,28
]}

Eskelinen, Eeva-Liisa ^{[29
]}

Fimia, Gian Maria ^{[30
,31
]}

Fulda, Simone ^{[32
,33
,34
]}

Gewirtz, David A. ^{[35
,36
]}

Green, Douglas R. ^{[37
]}

Hansen, Malene ^{[38
]}

Harper, J. Wade ^{[39
]}

Jaattela, Marja ^{[40
]}

Johansen, Terje ^{[41
]}

Juhasz, Gabor ^{[42
,43
]}

Kimmelman, Alec C. ^{[44
]}

Kraft, Claudine ^{[45
]}

Ktistakis, Nicholas T. ^{[46
]}

Kumar, Sharad ^{[47
]}

Levine, Beth ^{[48
,49
]}

Lopez-Otin, Carlos ^{[50
,51
]}

Madeo, Frank ^{[52
,53
]}

Martens, Sascha ^{[45
]}

Martinez, Jennifer ^{[54
]}

Melendez, Alicia ^{[55
,56
]}

Mizushima, Noboru ^{[57
,58
]}

Munz, Christian ^{[59
]}

Murphy, Leon O. ^{[60
]}

Penninger, Josef M. ^{[61
]}

Piacentini, Mauro ^{[13
,30
]}

Reggiori, Fulvio ^{[62
]}

Rubinsztein, David C. ^{[63
]}

Ryan, Kevin M. ^{[64
]}

Santambrogio, Laura ^{[65
]}

Scorrano, Luca ^{[66
,67
]}

Simon, Anna Katharina ^{[68
,69
]}

Simon, Hans-Uwe ^{[70
]}

Simonsen, Anne ^{[71
]}

Tavernarakis, Nektarios ^{[72
,73
]}

Tooze, Sharon A. ^{[74
]}

Yoshimori, Tamotsu ^{[75
,76
]}

机构：

[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[2] Univ Paris Descartes Paris V, Paris, France

[3] Univ Massachusetts, Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA

[4] Telethon Inst Genet & Med TIGEM, Pozzuoli, Italy

[5] Univ Naples Federico II, Dept Pediat, Med Genet, Naples, Italy

[6] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[7] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA

[8] CSIC, Ctr Invest Biol, Dept Cellular & Mol Biol, Madrid, Spain

[9] Univ Pierre & Marie Curie Paris VI, Paris, France

[10] Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, Paris, France

[11] INSERM, U1138, Paris, France

[12] Gustave Roussy Comprehens Canc Inst, Metabol & Cell Biol Platforms, Villejuif, France

[13] Univ Tor Vergata, Dept Biol, Rome, Italy

[14] Danish Canc Soc Res Ctr, Unit Cell Stress & Survival, Copenhagen, Denmark

[15] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat Hematol & Oncol, Rome, Italy

[16] Weill Cornell Med Coll, Joan & Sanford I Weill Dept Med, Div Pulm & Crit Care Med, New York, NY USA

[17] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[18] Inst Necker Enfants Malades INEM, Paris, France

[19] INSERM, U1151, Paris, France

[20] CNRS, UMR8253, Paris, France

[21] Consejo Nacl Invest Cient & Tecn, Inst Histol & Embriol IHEM, Lab Biol Celular & Mol, Mendoza, Argentina

[22] Univ Nacl Cuyo, Fac Ciencias Med, Mendoza, Argentina

[23] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10467 USA

[24] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[25] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[26] Goethe Univ Frankfurt, Sch Med, Inst Biochem 2, Frankfurt, Germany

[27] Goethe Univ Frankfurt, Buchmann Inst Mol Life Sci, Frankfurt, Germany

[28] Univ Split, Sch Med, Dept Immunol & Med Genet, Split, Croatia

[29] Univ Helsinki, Dept Biosci, Helsinki, Finland

[30] Nat Inst Infect Dis L Spallanzani IRCCS, Rome, Italy

[31] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Lecce, Italy

[32] Goethe Univ, Inst Expt Canc Res Pediat, Frankfurt, Germany

[33] German Canc Consortium DKTK, Heidelberg, Germany

[34] German Canc Res Ctr, Heidelberg, Germany

[35] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol & Med, Richmond, VA USA

[36] Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA USA

[37] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA

[38] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA USA

[39] Harvard Med Sch, Dept Cell Biol, Boston, MA USA

[40] Danish Canc Soc Res Ctr, Ctr Autophagy Recycling & Dis, Cell Death & Metab Unit, Copenhagen, Denmark

[41] Univ Tromso, Arctic Univ Norway, Inst Med Biol, Mol Canc Res Grp, Tromso, Norway

[42] Eotvos Lorand Univ, Dept Anat Cell & Dev Biol, Budapest, Hungary

[43] Hungarian Acad Sci, Biol Res Ctr, Inst Genet, Szeged, Hungary

[44] NYU, Langone Med Ctr, Perlmutter Canc Ctr, Dept Radiat Oncol, New York, NY USA

[45] Univ Vienna, Vienna Bioctr, Dept Biochem & Cell Biol, Max F Perutz Labs, Vienna, Austria

[46] Babraham Inst, Signalling Programme, Cambridge, England

[47] Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia

[48] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Ctr Autophagy Res, Dallas, TX 75390 USA

[49] Howard Hughes Med Inst, Dallas, TX USA

[50] Univ Oviedo, Inst Univ Oncol IUOPA, Fac Med, Dept Bioquim & Biol Mol, Oviedo, Spain

来源：

EMBO JOURNAL | 2017年 / 36卷 / 13期

基金：

英国生物技术与生命科学研究理事会;

关键词：

chaperone-mediated autophagy; LC3-associated phagocytosis; microautophagy; mitophagy; xenophagy; CHAPERONE-MEDIATED AUTOPHAGY; PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES; ENDOPLASMIC-RETICULUM TURNOVER; SELECTIVE AUTOPHAGY; CELL-DEATH; RECEPTOR NDP52; PIECEMEAL MICROAUTOPHAGY; REGULATES AUTOPHAGY; C; ELEGANS; LIR MOTIF;

D O I：

10.15252/embj.201796697

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

引用

页码：1811 / 1836

页数：26

共 374 条

[1]

An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation [J].

Agarraberes, FA ;

Terlecky, SR ;

Dice, JF .

JOURNAL OF CELL BIOLOGY, 1997, 137 (04) :825-834

[2]

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission [J].

Al Rawi, Sara ;

Louvet-Vallee, Sophie ;

Djeddi, Abderazak ;

Sachse, Martin ;

Culetto, Emmanuel ;

Hajjar, Connie ;

Boyd, Lynn ;

Legouis, Renaud ;

Galy, Vincent .

SCIENCE, 2011, 334 (6059) :1144-1147

[3]

Recent insights into the function of autophagy in cancer [J].

Amaravadi, Ravi ;

Kimmelman, Alec C. ;

White, Eileen .

GENES & DEVELOPMENT, 2016, 30 (17) :1913-1930

[4]

Autophagy and proteins involved in vesicular trafficking [J].

Amaya, Celina ;

Marcelo Fader, Claudio ;

Isabel Colombo, Maria .

FEBS LETTERS, 2015, 589 (22) :3343-3353

[5]

Emerging Mechanisms in Initiating and Terminating Autophagy [J].

Antonioli, Manuela ;

Di Rienzo, Martina ;

Piacentini, Mauro ;

Fimia, Gian Maria .

TRENDS IN BIOCHEMICAL SCIENCES, 2017, 42 (01) :28-41

[6]

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy [J].

Arias, Esperanza ;

Koga, Hiroshi ;

Diaz, Antonio ;

Mocholi, Enric ;

Patel, Bindi ;

Cuervo, Ana Maria .

MOLECULAR CELL, 2015, 59 (02) :270-284

[7]

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance [J].

Arndt, Verena ;

Dick, Nikolaus ;

Tawo, Riga ;

Dreiseidler, Michael ;

Wenzel, Daniela ;

Hesse, Michael ;

Fuerst, Dieter O. ;

Saftig, Paul ;

Saint, Robert ;

Fleischmann, Bernd K. ;

Hoch, Michael ;

Hoehfeld, Joerg .

CURRENT BIOLOGY, 2010, 20 (02) :143-148

[8]

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[9]

Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes [J].

Bader, C. A. ;

Shandala, T. ;

Ng, Y. S. ;

Johnson, I. R. D. ;

Brooks, D. A. .

BIOLOGY OPEN, 2015, 4 (11) :1345-1355

[10]

Ubiquitin-Mediated Response to Microsporidia and Virus Infection in C. elegans [J].

Bakowski, Malina A. ;

Desjardins, Christopher A. ;

Smelkinson, Margery G. ;

Dunbar, Tiffany A. ;

Lopez-Moyado, Isaac F. ;

Rifkin, Scott A. ;

Cuomo, Christina A. ;

Troemel, Emily R. .

PLOS PATHOGENS, 2014, 10 (06)

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