Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

被引：64

作者：

Kubota, S

Kawata, K

Yanagita, T

Doi, H

Kitoh, T

Takigawa, M ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Biochem & Mol Dent, Okayama 7008525, Japan

[2] Nichirei Corp, Biosci Res & Dev Ctr, Tokyo 1800003, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2004年 / 136卷 / 03期

关键词：

CCN2; CTGF; platelet; tissue regeneration; wound healing;

D O I：

10.1093/jb/mvh126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of the major functional components of platelets.

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页码：279 / 282

页数：4

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