Cell-permeable GPNA with appropriate backbone stereochemistry and spacing binds sequence-specifically to RNA

被引：71

作者：

Dragulescu-Andrasi, A ^{[1
]}

Zhou, P ^{[1
]}

He, GF ^{[1
]}

Ly, DH ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 02期

关键词：

D O I：

10.1039/b412522c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Guanidine-based peptide nucleic acid (GPNA) with a D-backbone configuration and alternate spacing binds sequence-specifically to RNA and is readily taken up by both human somatic and embryonic stem (ES) cells.

引用

页码：244 / 246

页数：3

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