Synthesis and DNA binding properties of a cationic 2,2′:6′,2"-terpyridine, cobalt(II) complex containing an oligopeptide

被引：10

作者：

Gao, H ^{[1
]}

Reibenspies, JH ^{[1
]}

Martell, AE ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2003年 / 94卷 / 03期

关键词：

intercalator; oligopeptide; cobalt(II) complex; binding ct-DNA; anti-tumor activity;

D O I：

10.1016/S0162-0134(03)00008-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first example of DNA metallointercalator containing an oligopeptide moiety is presented. The ternary cobalt(II) complex [(DOTA)Co(II)(TPY)] (ClO4)(2) (DOTA=1,4,7,10-tetraaza-cyclododecane-2,9-dione, TPY=2, 2':6',2"-terpyridine) was found to be efficient in binding ct-DNA. The binding constant was determined by spectrophotometric titration. In vitro antitumor studies shows that this complex has significant antitumor activity. The single-crystal of a six coordinated oligopeptide cobalt(II) complex [Co(II)(DOTA)(2)](ClO4)(2) is also reported. The stabilities and species distributions of Co(II)-DOTA (1:1) and DOTA-Co(II)-TPY (1:1:1) systems were investigated by potentiometry titration. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：272 / 278

页数：7

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