Solution-phase parallel synthesis using ion-exchange resins

被引：46

作者：

Suto, MJ ^{[1
]}

Gayo-Fung, LM ^{[1
]}

Palanki, MSS ^{[1
]}

Sullivan, R ^{[1
]}

机构：

[1] Signal Pharmaceut Inc, Dept Med Chem, San Diego, CA 92121 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(98)00141-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. Several compound libraries have been prepared using the basic ion-exchange resin Amberlyst 21 as part of our lead optimization program. The utility of ion-exchange resins as a means of generating both large and small focused libraries will be reviewed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4141 / 4150

页数：10

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