Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

被引：36

作者：

Goluszko, P

Goluszko, E

Nowicki, B

Nowicki, S

Popov, V

Wang, HQ

机构：

[1] Univ Texas, Med Branch, Dept Obstet & Gynecol, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[3] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

[4] Univ Texas, Med Branch, Dept Res Histopathol Core, Galveston, TX 77555 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 01期

关键词：

D O I：

10.1128/IAI.73.1.627-631.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

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页码：627 / 631

页数：5

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