Direct amino acid catalyzed asymmetric α oxidation of ketones with molecular oxygen

被引：127

作者：

Sundén, H ^{[1
]}

Engqvist, M ^{[1
]}

Casas, J ^{[1
]}

Ibrahem, I ^{[1
]}

Córdova, A ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 47期

关键词：

amino acids; asymmetric catalysis; ketones; molecular oxygen; oxidation;

D O I：

10.1002/anie.200460295

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical equation presented). A possible prebiotic pathway for the asymmetric incorporation of molecular oxygen into organic compounds involves the amino acid catalyzed reaction of molecular singlet oxygen with ketones. Amino acids and their derivatives mediate the reaction between oxygen and ketones with high efficiency to produce α-hydroxyketones (see scheme).

引用

页码：6532 / 6535

页数：4

共 51 条

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