Synthesis of deuterated 4,4′-diaminodiphenylsulfone (Dapsone) and related analogs

被引：4

作者：

Gannett, PM ^{[1
]}

Johnson, EM ^{[1
]}

Grimes, MA ^{[1
]}

Myers, AL ^{[1
]}

Deavers, RE ^{[1
]}

Tracy, TS ^{[1
]}

机构：

[1] W Virginia Univ, Sch Pharm, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2003年 / 46卷 / 02期

关键词：

4,4 '-diaminophenyl sulfone; Dapsone; deuterated; synthesis;

D O I：

10.1002/jlcr.649

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A general scheme for the synthesis of 4,4'-diaminodiphenylsulfone-d(5) (Dapsone) from aniline-d(5) is described. The method may have general application and the preparation of the related analogs, 4,4'-dimethylaminodiphenyl sulfone from aniline-d(5) and 4,4'-dimethoxydiphenyl sulfone from phenol-d(5), is also described. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：107 / 114

页数：8

共 9 条

[1] A SIMPLIFIED PREPARATION OF FULLY DEUTERATED HIGH MOLECULAR WEIGHT HYDROCARBONS [J].

ATKINSON, JG ;

LUKE, MO ;

STUART, RS .

CANADIAN JOURNAL OF CHEMISTRY, 1967, 45 (13) :1511-&

[2] PLATINUM-CATALYZED EXCHANGE OF AROMATIC COMPOUNDS WITH DEUTERIUM OXIDE [J].

BROWN, WG ;

GARNETT, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (19) :5272-5274

[3]

FISCHER G, 1973, SYNTHESIS-STUTTGART, P218

[4] PREPARATION OF DEUTERATED AROMATIC-HYDROCARBONS, HETEROATOM-CONTAINING AROMATICS, AND POLYCHLORINATED-BIPHENYLS AS INTERNAL STANDARDS FOR GC/MS ANALYSIS [J].

HAWTHORNE, SB ;

MILLER, DJ ;

AULICH, TR .

FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1989, 334 (05) :421-426

[5]

Hutzler JM, 2001, DRUG METAB DISPOS, V29, P1029

[6] Evaluation of atypical cytochrome P450 kinetics with two-substrate models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites [J].

Korzekwa, KR ;

Krishnamachary, N ;

Shou, M ;

Ogai, A ;

Parise, RA ;

Rettie, AE ;

Gonzalez, FJ ;

Tracy, TS .

BIOCHEMISTRY, 1998, 37 (12) :4137-4147

[7]

PETROS AM, 1994, METHOD ENZYMOL, V239, P717

[8]

SANGHAVI NM, 1971, INDIAN CHEM J, V6, P179

[9]

Winter HR, 2000, DRUG METAB DISPOS, V28, P865

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