The endothelin axis: Emerging role in cancer

被引：455

作者：

Nelson, J

Bagnato, A

Battistini, B

Nisen, P

机构：

[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USA

[2] Regina Elena Inst Canc Res, Lab Mol Pathol & Ultrastruct, I-00158 Rome, Italy

[3] Univ Laval, Laval Hosp, Res Ctr, Quebec Heart & Lung Inst, Ste Foy, PQ G1V 4G5, Canada

[4] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 02期

关键词：

D O I：

10.1038/nrc990

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Collectively, the endothelins and their receptors-referred to as the endothelin (ET) axis-have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell proliferation and hormone production. Based on new data, the ET axis also functions in the growth and progression of various tumours. Preliminary results from clinical trials, such as those with atrasentan-an ETA-receptor antagonist-in prostate cancer, are encouraging. The place of ETA-receptor antagonists in cancer therapy for a range of malignancies merits further investigation.

引用

页码：110 / 116

页数：7

共 76 条

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