Inhibition of dopamine receptors by endogenous amines: Binding to striatal receptors and pharmacological effects on locomotor activity

被引：12

作者：

Kawai, H

Kotake, Y

Ohta, S ^{[1
]}

机构：

[1] Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Hiroshima 7348551, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(00)00326-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Endogenous amine 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) derivatives are synthesized, and their activity for dopaminergic systems are evaluated in vitro and in vivo by receptor binding assay and pharmacological tests. It is proposed that 1BnTIQ derivatives can act as endogenous dopaminergic antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1669 / 1671

页数：3

共 24 条

[1] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF [H-3] GBR-12935 BINDING INVITRO TO RAT STRIATAL MEMBRANES - LABELING OF THE DOPAMINE UPTAKE COMPLEX [J].