Regulation of poly(A)-binding protein through PABP-interacting proteins

被引:92
作者
Derry, M. C. [1 ]
Yanagiya, A.
Martineau, Y.
Sonenberg, N.
机构
[1] McGill Univ, Dept Biochem, Montreal, PQ H6G 1Y6, Canada
[2] McGill Univ, McGill Canc Ctr, Montreal, PQ H6G 1Y6, Canada
关键词
D O I
10.1101/sqb.2006.71.061
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Translation initiation requires the participation of eukaryotic translation initiation factors (eIFs). The poly(A)-binding protein (PABP) is thought to stimulate translation by promoting mRNA circularization through simultaneous interactions with eIF4G and the 3' poly(A) tail. PABP activity is regulated by the PABP-interacting proteins (Paips), a family of proteins consisting of Paip1, a translational stimulator, and Paip2A and Paip2B, two translational inhibitors. Paip2A controls PABP homeostasis Via ubiquitination. When the cellular concentration of PABP is reduced, Paip2A becomes ubiquitinated and degraded, resulting in the relief of PABP repression. Paip1 interacts with eIF4A and eIF3, which promotes translation. The regulation of PABP activity by Paips represents the first known mechanism for controlling PABP, adding a new layer to the existing knowledge of PABP function.
引用
收藏
页码:537 / 543
页数:7
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