Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

被引：1348

作者：

Dubois, Bruno ^{[1
,2
]}

Hampel, Harald ^{[1
,2
,3
,4
]}

Feldman, Howard H. ^{[5
]}

Scheltens, Philip ^{[6
,7
]}

Aisen, Paul ^{[8
]}

Andrieu, Sandrine ^{[9
]}

Bakardjian, Hovagim ^{[10
]}

Benali, Habib ^{[11
]}

Bertram, Lars ^{[12
,13
,14
]}

Blennow, Kaj ^{[15
]}

Broich, Karl ^{[16
]}

Cavedo, Enrica ^{[3
,4
,17
]}

Crutch, Sebastian ^{[18
]}

Dartigues, Jean-Francois ^{[19
]}

Duyckaerts, Charles ^{[20
]}

Epelbaum, Stephane ^{[1
,2
]}

Frisoni, Giovanni B. ^{[21
,22
,23
]}

Gauthier, Serge ^{[24
]}

Genthon, Remy ^{[25
]}

Gouw, Alida A. ^{[9
,26
]}

Habert, Marie-Odile ^{[27
,28
]}

Holtzman, David M. ^{[29
,30
]}

Kivipelto, Miia ^{[31
,32
]}

Lista, Simone ^{[3
,4
]}

Molinuevo, Jose-Luis ^{[33
,34
]}

O'Bryant, Sid E. ^{[35
]}

Rabinovici, Gil D. ^{[36
]}

Rowe, Christopher ^{[37
]}

Salloway, Stephen ^{[38
,39
,40
]}

Schneider, Lon S. ^{[41
]}

Sperling, Reisa ^{[42
,43
]}

Teichmann, Marc ^{[1
,2
]}

Carrillo, Maria C. ^{[44
]}

Cummings, Jeffrey ^{[45
]}

Jack, Cliff R., Jr. ^{[46
]}

机构：

[1] Univ Paris 06, Pitie Salpetriere Univ Hosp, AP HP, Inst Memory & Alzheimers Dis IM2A, Paris, France

[2] Univ Paris 06, Pitie Salpetriere Univ Hosp, AP HP, Brain & Spine Inst ICM,Frontlab,Dept Neurol,UMR S, Paris, France

[3] AXA Res Fund, Paris, France

[4] UPMC, Paris, France

[5] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[6] Vrije Univ Amsterdam Med Ctr, Dept Neurol & Alzheimer Ctr, Amsterdam, Netherlands

[7] Neurosci Campus, Dept Neurol & Alzheimer Ctr, Amsterdam, Netherlands

[8] Univ Southern Calif San Diego, San Diego, CA USA

[9] Univ Toulouse 3, Toulouse Univ Hosp, INSERM, UMR1027, F-31062 Toulouse, France

[10] Inst Neurosci Translat Paris, IIIU A ICM, Paris, France

[11] UPMC UM CR2, CNRS UMR 7371, INSERM U1146, Site Pitie Salpetriere, Paris, France

[12] Med Univ Lubeck, Inst Neurogenet, Lubeck Interdisciplinary Platform Genome Analyt L, D-23538 Lubeck, Germany

[13] Med Univ Lubeck, Inst Integrat & Expt Genom, Lubeck Interdisciplinary Platform Genome Analyt L, D-23538 Lubeck, Germany

[14] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, London, England

[15] Univ Gothenburg, Molndal Hosp, Sahlgrenska Univ Hosp, Clin Neurochem Lab,Dept Neurosci & Physiol, Molndal, Sweden

[16] Fed Inst Drugs & Med Devices, Bonn, Germany

[17] IRCCS Ctr San Giovanni di Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[18] UCL, UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England

[19] Univ Bordeaux, INSERM U1219, Bordeaux, France

[20] Univ Paris 06, AP HP, Alzheimer Prion Team, ICM, Paris, France

[21] Univ Hosp Geneva, Geneva, Switzerland

[22] Univ Geneva, Geneva, Switzerland

[23] IRCCS Fatebenefratelli, Brescia, Italy

[24] McGill Ctr Studies Aging, Douglas Mental Hlth Res Inst, Montreal, PQ, Canada

[25] Hop La Pitie Salpetriere, Fdn Rech Alzheimer, Paris, France

[26] Vrije Univ Amsterdam Med Ctr, MEG Ctr, Dept Clin Neurophysiol, Amsterdam, Netherlands

[27] Univ Paris 06, Sorbonne Univ, CNRS, INSERM,Lab Imagerie Biomed, Paris, France

[28] Hop La Pitie Salpetriere, AP HP, Dept Nucl Med, Paris, France

[29] Washington Univ, Dept Neurol, Hope Ctr Neurol Disorders, St Louis, MO USA

[30] Washington Univ, Dept Neurol, Knight Alzheimers Dis Res Ctr St, St Louis, MO USA

[31] Karolinska Univ Hosp, Dept Geriatr Med, Karolinska Inst, Ctr Alzheimer Res, Stockholm, Sweden

[32] Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

[33] Hosp Clin Barcelona, IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

[34] Pasqual Maragall Fdn, Barcelonabeta Brain Res Ctr, Barcelona, Spain

[35] Univ N Texas, Hlth Sci Ctr, Ctr Alzheimers & Neurodegenerat Dis Res, Denton, TX 76203 USA

[36] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA

[37] Univ Melbourne, Austin Hlth, Dept Mol Imaging, Melbourne, Vic 3010, Australia

[38] Brown Univ, Alpert Med Sch, Butler Hosp, Memory & Aging Program, Providence, RI 02912 USA

[39] Brown Univ, Alpert Med Sch, Dept Neurol, Providence, RI 02912 USA

[40] Brown Univ, Alpert Med Sch, Dept Psychiat, Providence, RI 02912 USA

[41] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[42] Harvard Univ, Brigham & Womens Hosp, Sch Med, Memory Disorders Unit,Ctr Alzheimer Res & Treatme, Boston, MA 02115 USA

[43] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Memory Disorders Unit,Ctr Alzheimer Res & Treatme, Boston, MA USA

[44] Alzheimers Assoc Div Med & Sci Relat, Chicago, IL USA

[45] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

[46] Mayo Clin, Dept Radiol, Rochester, MN USA

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 03期

关键词：

Alzheimer's disease; Preclinical; Asymptomatic; Diagnostic criteria; Biomarkers; Pathophysiology; Genetics; CSF biomarkers; Blood biomarkers; MRI; Amyloid PET; Tau PET; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; POSITRON-EMISSION-TOMOGRAPHY; BLOOD-BASED BIOMARKERS; BETA-AMYLOID; 1-42; SECONDARY PREVENTION TRIALS; GINKGO-BILOBA EXTRACT; DEFAULT-MODE NETWORK; APOLIPOPROTEIN-E; FUNCTIONAL CONNECTIVITY;

D O I：

10.1016/j.jalz.2016.02.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：292 / 323

页数：32

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