Sister chromatid exchange induction in peripheral blood lymphocytes of traffic police workers

被引:24
作者
Bolognesi, C
Gallerani, E
Bonatti, S
De Ferrari, M
Fontana, V
Valerio, F
Merlo, F
Abbondandolo, A
机构
[1] Ist Nazl Ric Canc, Toxicol Evaluat Unit, Environm Oncol Dept, I-16132 Genoa, Italy
[2] Ist Nazl Ric Canc, Environm Oncol Dept, Mutagenesis Lab, I-16132 Genoa, Italy
[3] Inst Mutagenesis & Differentiat, CNR, Pisa, Italy
[4] Univ Genoa, Chair Genet, Genoa, Italy
关键词
sister chromatid exchange; traffic policeman; cytogenetic biomonitoring;
D O I
10.1016/S1383-5718(97)00121-6
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Traffic police workers, as a population exposed to urban atmosphere, were compared with a control population exposed to indoor air pollution levels. Sister chromatid exchanges (SCEs) as a biomarker of effect were measured in peripheral blood lymphocytes of 54 exposed subjects and 35 controls, and environmental concentration of polynuclear aromatic hydrocarbon (PAH) tracer compounds was detected by personal air samplers. The mean exposure level to benzol[a]pyrene in our group of traffic policemen (3.4 mg/m(3)) was in the range that has been estimated in urban areas in Europe during the last 10 years. No difference in SCE levels was found between exposed workers (7.36, SD 1.35) and controls (7.47, SD 1.28). No correlation was observed between SCE/cell and airborne PAH concentration in the traffic worker population. A positive regression of SCE on exposure estimate was found only in the non-smoking group of police workers. Our findings suggest that exposure to urban air pollution does not induce relevant cytogenetic effects. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:37 / 44
页数:8
相关论文
共 36 条
[1]   CYTOGENETIC EFFECTS IN A GROUP OF TRAFFIC POLICEMEN IN CAIRO [J].
ANWAR, WA ;
KAMAL, AAM .
MUTATION RESEARCH, 1988, 208 (3-4) :225-231
[2]   CHROMOSOMAL-ABERRATIONS AND SISTER-CHROMATID EXCHANGES IN LYMPHOCYTES FROM COKE-OVEN WORKERS [J].
BENDER, MA ;
LEONARD, RC ;
WHITE, O ;
COSTANTINO, JP ;
REDMOND, CK .
MUTATION RESEARCH, 1988, 206 (01) :11-16
[3]   Increased sister chromatid exchange (SCE) frequencies in lymphocytes from traffic policemen exposed to automobile exhaust pollution [J].
Chandrasekaran, R ;
Samy, PLP ;
Murthy, PBK .
HUMAN & EXPERIMENTAL TOXICOLOGY, 1996, 15 (04) :301-304
[4]   PULMONARY-FUNCTION AND AMBIENT PARTICULATE MATTER - EPIDEMIOLOGIC EVIDENCE FROM NHANES-I [J].
CHESTNUT, LG ;
SCHWARTZ, J ;
SAVITZ, DA ;
BURCHFIEL, CM .
ARCHIVES OF ENVIRONMENTAL HEALTH, 1991, 46 (03) :135-144
[5]   AN ASSOCIATION BETWEEN AIR-POLLUTION AND MORTALITY IN 6 UNITED-STATES CITIES [J].
DOCKERY, DW ;
POPE, CA ;
XU, XP ;
SPENGLER, JD ;
WARE, JH ;
FAY, ME ;
FERRIS, BG ;
SPEIZER, FE .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (24) :1753-1759
[7]   Cytogenetic studies in coke oven workers [J].
Forni, A ;
Guanti, G ;
Bukvic, N ;
Ferri, G ;
Foa, V .
TOXICOLOGY LETTERS, 1996, 88 (1-3) :185-189
[8]  
FRANCIS B, 1994, GLIM SYSTEM RELEASE
[9]   PARTICLE-ASSOCIATED POLYCYCLIC AROMATIC-HYDROCARBONS - A REAPPRAISAL OF THEIR POSSIBLE ROLE IN PULMONARY CARCINOGENESIS [J].
GERDE, P ;
MEDINSKY, MA ;
BOND, JA .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 108 (01) :1-13
[10]  
GOLDSMITH JR, 1980, CANCER ENV ACADEMIC, P205