Neoadjuvant Therapy of Locally Advanced Gastric Cancer

被引：80

作者：

Mezhir, James J.

Tang, Laura H. ^{[1
]}

Coit, Daniel G. ^{[2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 101卷 / 04期

关键词：

gastric cancer; neoadjuvant therapy; chemotherapy; gastrectomy; cytology; PHASE-II TRIAL; POSTOPERATIVE INTRAPERITONEAL THERAPY; INTRA-ARTERIAL INFUSION; CURATIVE RESECTION; PERIOPERATIVE CHEMOTHERAPY; PREOPERATIVE CHEMOTHERAPY; ESOPHAGOGASTRIC JUNCTION; RANDOMIZED-TRIAL; SYSTEMIC CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY;

D O I：

10.1002/jso.21483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of gastric cancer has evolved with the advent of randomized trials demonstrating chemotherapeutic agents with efficacy in advanced disease. Level I evidence Supports delivering chemotherapy in the neoadjuvant settings the data shows improvement in progression-free and overall survival. A clinical response to therapy is associated with improved R0 resection rates, pathologic response. and outcome in patients with locally advanced disease. Early assessment of metabolic response to therapy can potentially be utilized to tailor treatment. J. Surg. Oncol. 2010; 101:305-314. (C) 2010 Wiley-Liss, Inc.

引用

页码：305 / 314

页数：10

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