Membrane sorting - Endosome marker is fat not fiction

被引：19

作者：

Schmid, SL

Cullis, PR

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Univ British Columbia, Dept Biochem, Vancouver, BC V6T 1Z3, Canada

来源：

NATURE | 1998年 / 392卷 / 6672期

关键词：

D O I：

10.1038/32309

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Every organelle in a eukaryotic cell contains enzymes with specialized functions, unique to that organelle. But the endosome does things differently — it is regulated, in part, by a unique lipid called lysobisphosphatidic acid (LBPA). This lipid seems to be crucial, because anti-LBPA antibodies affect both the structure and function of the late endosome. Moreover, LBPA is recognized by autoimmune sera from patients with antiphospholipid syndrome, indicating that it may be involved in pathogenesis of this disease.

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页码：135 / 136

页数：2

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