Family history as a risk factor for ulcerative colitis-associated colon cancer in cotton-top tamarin

Background & Aims: Little is currently known about the relationship between family history of colon cancer and ulcerative colitis-associated colon cancer, A nested case-control study was performed to evaluate the association between family history of colon cancer and spontaneously occurring colon cancer in cotton-top tamarins (Saguinus oedipus). Methods: Subjects were chosen from a colony of cotton-top tamarins held in captivity between 1968 and 1995, The cancer status of parents and grandparents was compared for 48 animals with colon cancer and 58 controls, all with histological confirmation of ulcerative colitis. Multivariate odds ratios were calculated using logistic regression. Results: A parental history of colon cancer was positively associated with risk of colon cancer (multivariate odds ratio, 2.7; 95% confidence interval, 1.1-6.3), Risk also increased as an animal's total number of family members with colon cancer increased (multivariate odds ratio, 1.7 for each increase in the total number of family members with cancer; 95% confidence interval, 1.1-2.8). Conclusions: The results suggest that cotton-top tamarins with ulcerative colitis are at significant increased risk for developing colon cancer if they have a family history of colon cancer. Further investigation of this relationship in both tamarins and humans is warranted.