An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer

被引：130

作者：

Asquith, Mark ^{[1
]}

Powrie, Fiona ^{[1
,2
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Univ Oxford, Translat Gastroenterol Unit, Nuffield Dept Clin Med, Oxford OX3 9DU, England

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2010年 / 207卷 / 08期

基金：

英国惠康基金;

关键词：

TOLL-LIKE RECEPTORS; CROHNS-DISEASE; HOST-DEFENSE; SUSCEPTIBILITY; MICE; TUMORIGENESIS; RECOGNITION; VARIANTS; IMMUNITY; MYD88;

D O I：

10.1084/jem.20101330

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms.

引用

页码：1573 / 1577

页数：5

共 43 条

[1]

ALLEN ICE, 2010, CANCER J, V207, P1045, DOI DOI 10.1084/JEM.20100050

[2]

ASQUITH MJ, 2010, GASTROENTER IN PRESS

[3]

MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection [J].

Brandl, Katharina ;

Plitas, George ;

Schnabl, Bernd ;

DeMatteo, Ronald P. ;

Pamer, Eric G. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1891-1900

[4]

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury [J].

Brown, Sarah L. ;

Riehl, Terrence E. ;

Walker, Monica R. ;

Geske, Michael J. ;

Doherty, Jason M. ;

Stenson, William F. ;

Stappenbeck, Thaddeus S. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (01) :258-269

[5]

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function [J].

Cario, E. ;

Gerken, G. ;

Podolsky, D. K. .

GASTROENTEROLOGY, 2007, 132 (04) :1359-1374

[6]

Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction [J].

Cario, Elke .

CURRENT OPINION IN GASTROENTEROLOGY, 2008, 24 (06) :725-732

[7]

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases [J].

De Jager, P. L. ;

Franchimont, D. ;

Waliszewska, A. ;

Bitton, A. ;

Cohen, A. ;

Langelier, D. ;

Belaiche, J. ;

Vermeire, S. ;

Farwell, L. ;

Goris, A. ;

Libioulle, C. ;

Jani, N. ;

Dassopoulos, T. ;

Bromfield, G. P. ;

Dubois, B. ;

Cho, J. H. ;

Brant, S. R. ;

Duerr, R. H. ;

Yang, H. ;

Rotter, J. I. ;

Silverberg, M. S. ;

Steinhart, A. H. ;

Daly, M. J. ;

Podolsky, D. K. ;

Louis, E. ;

Hafler, D. A. ;

Rioux, J. D. .

GENES AND IMMUNITY, 2007, 8 (05) :387-397

[8]

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases [J].

Dupaul-Chicoine, Jeremy ;

Yeretssian, Garabet ;

Doiron, Karine ;

Bergstrom, Kirk S. B. ;

McIntire, Christian R. ;

LeBlanc, Philippe M. ;

Meunier, Charles ;

Turbide, Claire ;

Gros, Philippe ;

Beauchemin, Nicole ;

Vallance, Bruce A. ;

Saleh, Maya .

IMMUNITY, 2010, 32 (03) :367-378

[9]

Function of Nod-like receptors in microbial recognition and host defense [J].

Franchi, Luigi ;

Wamer, Neil ;

Viani, Kyle ;

Nunez, Gabriel .

IMMUNOLOGICAL REVIEWS, 2009, 227 :106-128

[10]

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis [J].

Fukata, M ;

Michelsen, KS ;

Eri, R ;

Thomas, LS ;

Hu, B ;

Lukasek, K ;

Nast, CC ;

Lechago, J ;

Xu, RL ;

Naiki, Y ;

Soliman, A ;

Arditi, M ;

Abreu, MT .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 288 (05) :G1055-G1065

← 1 2 3 4 5 →