Variant LTC4 synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast

被引:165
作者
Sampson, AP
Siddiqui, S
Buchanan, D
Howarth, PH
Holgate, ST
Holloway, JW
Sayers, I
机构
[1] Univ Southampton, Sch Med, Div Resp Cell & Mol Biol Res, Southampton SO9 5NH, Hants, England
[2] Univ Southampton, Sch Med, Div Human Genet, Southampton SO9 5NH, Hants, England
关键词
D O I
10.1136/thorax.55.suppl_2.S28
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
引用
收藏
页码:S28 / S31
页数:4
相关论文
共 17 条
[1]  
Bazan-Socha S., 1998, European Journal of Clinical Investigation, V28, pA50
[2]  
Boyce JA, 1996, BLOOD, V88, P4338
[3]   Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma [J].
Cowburn, AS ;
Sladek, K ;
Soja, J ;
Adamek, L ;
Nizankowska, E ;
Szczeklik, A ;
Lam, BK ;
Penrose, JF ;
Austen, KF ;
Holgate, ST ;
Sampson, AP .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) :834-846
[4]  
Cowburn AS, 1999, J IMMUNOL, V163, P456
[5]   The effect of inhaled leukotriene D-4 and methacholine on sputum cell differentials in asthma [J].
Diamant, Z ;
Hiltermann, JT ;
vanRensen, EL ;
Callenbach, PM ;
VeselicCharvat, M ;
vanderVeen, H ;
Sont, JK ;
Sterk, PJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (04) :1247-1253
[6]   Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment [J].
Drazen, JM ;
Yandava, CN ;
Dubé, L ;
Szczerback, N ;
Hippensteel, R ;
Pillari, A ;
Israel, E ;
Schork, N ;
Silverman, ES ;
Katz, DA ;
Drajesk, J .
NATURE GENETICS, 1999, 22 (02) :168-170
[7]   Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription [J].
In, KH ;
Asano, K ;
Beier, D ;
Grobholz, J ;
Finn, PW ;
Silverman, EK ;
Silverman, ES ;
Collins, T ;
Fischer, AR ;
Keith, TP ;
Serino, K ;
Kim, SW ;
DeSanctis, GT ;
Yandava, C ;
Pillari, A ;
Rubin, P ;
Kemp, J ;
Israel, E ;
Busse, W ;
Ledford, D ;
Murray, JJ ;
Segal, A ;
Tinkleman, D ;
Drazen, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (05) :1130-1137
[8]   LEUKOTRIENE-E(4) AND GRANULOCYTIC INFILTRATION INTO ASTHMATIC AIRWAYS [J].
LAITINEN, LA ;
LAITINEN, A ;
HAAHTELA, T ;
VILKKA, V ;
SPUR, BW ;
LEE, TH .
LANCET, 1993, 341 (8851) :989-990
[9]   Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction [J].
Leff, JA ;
Busse, WW ;
Pearlman, D ;
Bronsky, EA ;
Kemp, JA ;
Hendeles, L ;
Dockhorn, R ;
Kundu, S ;
Zhang, J ;
Seidenberg, BC ;
Reiss, TF .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (03) :147-152
[10]  
Lynch KR, 1999, NATURE, V399, P789