Neutrophils release brakes of coagulation

被引：43

作者：

Ruf, Wolfram ^{[1
]}

Ruggeri, Zaverio M. ^{[2
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 08期

关键词：

P-SELECTIN; IN-VIVO; CD11B/CD18; PLATELETS; MEDIATORS; ALPHA; BLOOD;

D O I：

10.1038/nm0810-851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood coagulation protects from microbial infections. A recent study now shows that neutrophils fine tune the procoagulant response to invading pathogens (pages 887-896). Neutrophils degrade an inhibitor of coagulation, locally 'trapping' bacteria in small blood vessels. But they also increase blood clots in large vessels in the absence of infection, which may be relevant for the treatment of thrombosis.

引用

页码：851 / 852

页数：2

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