Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes

被引：26

作者：

Rabenstein, Monika ^{[1
]}

Unverricht-Yeboah, Marcus ^{[2
]}

Keuters, Meike Hedwig ^{[1
,3
,4
]}

Pikhovych, Anton ^{[1
,3
]}

Hucklenbroich, Joerg ^{[1
,5
]}

Vay, Sabine Ulrike ^{[1
]}

Blaschke, Stefan ^{[1
,3
,5
]}

Ladwig, Anne ^{[1
,3
]}

Walter, Helene Luise ^{[1
]}

Beiderbeck, Magdalena ^{[1
]}

Fink, Gereon Rudolf ^{[1
,5
]}

Schroeter, Michael ^{[1
,3
,5
]}

Kriehuber, Ralf ^{[2
]}

Rueger, Maria Adele ^{[1
,3
,5
]}

机构：

[1] Univ Hosp Cologne, Dept Neurol, Cologne, Germany

[2] Res Ctr Julich, Radiat Biol Unit, Dept Safety & Radiat Protect, Julich, Germany

[3] Max Planck Inst Metab Res, Cologne, Germany

[4] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland

[5] Res Ctr Julich, Cognit Neurosci, Inst Neurosci & Med INM 3, Julich, Germany

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2019年 / 13卷

关键词：

direct transcranial current stimulation; gene expression; microarray; MHC-I; osteopontin; transcriptome; MHC CLASS-I; CENTRAL-NERVOUS-SYSTEM; HUMAN MOTOR CORTEX; NEURAL STEM-CELLS; SYNAPTIC PLASTICITY; CEREBRAL-CORTEX; OSTEOPONTIN; RAT; INDUCTION; INFLAMMATION;

D O I：

10.3389/fncel.2019.00461

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate effects of tDCS regulating those cellular responses, we treated rats with a single session of either anodal or cathodal tDCS, and analyzed the gene expression by microarray; sham-stimulated rats served as control. Anodal tDCS increased expression of several genes coding for the major histocompatibility complex I (MHC I), while cathodal tDCS increased the expression of the immunoregulatory protein osteopontin (OPN). We confirmed the effects of gene upregulation by immunohistochemistry at the protein level. Thus, our data show a novel mechanism for the actions of tDCS on immune- and inflammatory processes, providing a target for future therapeutic studies.

引用

页数：8

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