Programmed drug delivery: nanosystems for tumor targeting

被引:107
作者
Wagner, Ernst
机构
[1] Univ Munich, Dept Pharm, D-81377 Munich, Germany
[2] Univ Munich, Ctr Nanosci, Munich, Germany
[3] Nanosyst Initiat Munich, Munich, Germany
关键词
bioresponsive drug delivery; controlled release; gene transfer; nanoparticles; polyethylene glycol shielding; receptor targeting; smart nanosystems; synthetic viruses; tumor therapy;
D O I
10.1517/14712598.7.5.587
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Programmed nanoscaled systems aria emerging that may be very useful for tumor-targeted drug delivery: novel nanoparticles are pre-programmed to alter their structure and properties during the drug delivery process to make them most effective for the different extra- and intracellular delivery steps. Programming is effected by the incorporation of molecular sensors that are able to respond to physical or biological stimuli, including changes in pH, redox potential or enzymes. Tumor-targeting principles include systemic passive targeting and active receptor targeting. Physical forces (e.g., electric or magnetic fields, ultrasound, hyperthermia or light) may contribute to focusing and triggered activation of nanosystems. Biological drugs delivered with programmed nanosystems also include plasmid DNA, small interfering RNA and related therapeutic nucleic acids formulated as 'synthetic viruses'.
引用
收藏
页码:587 / 593
页数:7
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