The zinspy family of fluorescent zinc sensors: Syntheses and spectroscopic investigations

被引：104

作者：

Nolan, EM ^{[1
]}

Lippard, SJ ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

INORGANIC CHEMISTRY | 2004年 / 43卷 / 26期

关键词：

D O I：

10.1021/ic048778z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Four fluorescent sensors designed for Zn(II) detection that contain a fluorescein reporting group and a pyridylamine-thioether derivatized ligand moiety were prepared and their photophysical properties characterized. These "Zinspy" sensors are water soluble and generally display similar to1.4- to similar to4.5-fold fluorescence enhancement upon Zn(II) coordination, depending upon fluorescein halogenation and the number and nature of the zinc-binding appendages. The Zinspy sensors exhibit improved selectivity for zinc compared to the di-(2-picolyl)amine-based Zinpyr family.

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页码：8310 / 8317

页数：8

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