A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation

被引：35

作者：

Folkesson, Ronnie

Malkiewicz, Katarzyna

Kloskowska, Ewa

Nilsson, Tatjana

Popova, Elena

Bogdanovic, Nenad

Ganten, Ursula

Ganten, Detlev

Bader, Michael

Winblad, Bengt

Benedikz, Eirikur

机构：

[1] Karolinska Inst, Dept Neurobiol Caring Sci & Soc, Div Neurodegenerat & Neuroinflammat, S-14186 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurobiol Caring Sci & Soc, S-14186 Stockholm, Sweden

[3] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 358卷 / 03期

关键词：

Alzheimer's disease; amyloid precursor protein; transgenic; rat; amyloid; tau;

D O I：

10.1016/j.bbrc.2007.04.195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex, hippocampus, and cerebellum. Starting after the age of 15 months, the rats show increased tau phosphorylation and extracellular A staining. The AP is found predominantly in cerebrovascular blood vessels with very rare diffuse plaques. We believe that crossing these animals with mutant PSI transgenic rats will result in accelerated plaque formation similar to that seen in transgenic mice. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：777 / 782

页数：6

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