Transfection of the plasma-type platelet-activating factor acetylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons

被引：16

作者：

Hirashima, Y ^{[1
]}

Ueno, H

Karasawa, K

Yokoyama, K

Setaka, M

Takaku, A

机构：

[1] Toyama Med & Pharmaceut Univ, Dept Neurosurg, Sugitani, Toyama 9300194, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Cardiol, Fukuoka 8128582, Japan

[3] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 1990106, Japan

来源：

BRAIN RESEARCH | 2000年 / 885卷 / 01期

关键词：

neurons; apoptosis; platelet-activating factor (PAF) acetylhydrolase; glutamate; mitochondrial damage;

D O I：

10.1016/S0006-8993(00)02852-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using an adenoviral vector, we induced overexpression of the plasma type of platelet-activating factor acetylhydrolase in cultured rat neurons. Neurons overexpressing this enzyme showed a decrease in glutamate-induced injury, mainly, apparent as decreased apoptosis. Reduction of lipid peroxidation by this enzyme and protection of mitochondrial function were demonstrated, and these may be the basis of the resistance to glutamate-induced neuronal injury that we observed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：128 / 132

页数：5

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