Difference in binding of killed and live Streptococcus pneumoniae serotypes by C-reactive protein

被引：8

作者：

de Beaufort, AJ ^{[1
]}

Langermans, JAM ^{[1
]}

Matze-Van der Lans, AM ^{[1
]}

Hiemstra, PS ^{[1
]}

Vossen, JM ^{[1
]}

Van Furth, R ^{[1
]}

机构：

[1] Leiden Univ Hosp, Dept Paediat, Neonatol Unit, NL-2300 RC Leiden, Netherlands

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1997年 / 46卷 / 06期

关键词：

D O I：

10.1046/j.1365-3083.1997.d01-171.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The binding and opsonic properties of C-reactive protein (CRP) for various species of bacteria were investigated. CRP bound more avidly to killed than to live Streptococcus pneumoniae, the binding varying among various serotypes; CRP hardly bound to a number of other bacterial species studied. CRP enhanced complement-dependent phagocytosis of live S. pneumoniae by granulocytes but did not enhance the phagocytosis of live Staphylococcus aureus or group B streptococci. We suppose that CRP may serve as an opsonin for killed bacteria and bacterial debris but is probably not an important opsonin for live bacteria other than S. pneumoniae.

引用

页码：597 / 600

页数：4

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