Interactions between decision making and performance monitoring within prefrontal cortex

被引:349
作者
Walton, ME
Devlin, JT
Rushworth, MFS
机构
[1] John Radcliffe Hosp, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England
[2] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/nn1339
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Our ability to judge the consequences of our actions is central to rational decision making. A large body of evidence implicates primate prefrontal regions in the regulation of this ability. It has proven extremely difficult, however, to separate functional areas in the frontal lobes. Using functional magnetic resonance imaging, we demonstrate complementary and reciprocal roles for the human orbitofrontal (OFC) and dorsal anterior cingulate cortices (ACd) in monitoring the outcome of behavior. Activation levels in these regions were negatively correlated, with activation increasing in the ACd and decreasing in the OFC when the selected response was the result of the participant's own decision. The pattern was reversed when the selected response was guided by the experimenter rather than the participant. These results indicate that the neural mechanisms underlying the way we assess the consequences of choices differ depending on whether we are told what to do or are able to exercise our volition.
引用
收藏
页码:1259 / 1265
页数:7
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