Myopathy associated with anti-signal recognition peptide antibodies: Clinical heterogeneity contrasts with stereotyped histopathology

被引：51

作者：

Dimitri, Dalia

Andre, Chantal

Roucoules, Jacques

Hosseini, Hassan

Humbel, Rene-Louis

Authier, Francois-Jerome

机构：

[1] CHU Henri Mondor, Ctr Reference Malad Neuromusculaires, Serv Histol, F-94010 Creteil, France

[2] CHU Henri Mondor, Serv Immunol Biol, F-94010 Creteil, France

[3] CH St Camille, Serv Rhumatol, Bry Sur Marne, France

[4] CHU Henri Mondor, Neurol Serv, F-94010 Creteil, France

[5] Lab Luxembourgeois Immunopathol, Esch Sur Alzette, Luxembourg

[6] Fac Med Creteil Paris 12, INSERM, E0011, Creteil, France

来源：

MUSCLE & NERVE | 2007年 / 35卷 / 03期

关键词：

anti-signal recognition peptide antibodies; anti-signal recognition peptide myopathy; anti-signal recognition peptide immune-mediated necrotizing myopathy;

D O I：

10.1002/mus.20693

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report three patients with anti-signal recognition particle antibodies who had different presenting clinical pictures, mimicking acute polymyositis, limb-girdle muscular dystrophy, and acute rhabdomyolysis. Muscle biopsies typically showed necrotizing myopathy with little or no inflammation and deposits of membrane attack complex (C5b-9) in endomysial capillaries. The clinical course was severe in two patients and mild in one. The combination of corticosteroid with either an immunosuppressive agent or intravenous immunoglobulins was required to improve the condition of these patients.

引用

页码：389 / 395

页数：7

共 20 条

[1]

Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition particle (SRP) [J].