Synthesis of pathogen inactivating nucleic acid intercalators

被引：4

作者：

Csuk, R ^{[1
]}

Barthel, A ^{[1
]}

Brezesinski, T ^{[1
]}

Raschke, C ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Organ Chem, D-06120 Halle An Der Saale, Saale, Germany

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 11期

关键词：

intercalators; antiviral agent; pathogen inactivation; acridines;

D O I：

10.1016/j.ejmech.2004.07.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：975 / 988

页数：14

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