Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus

被引：5

作者：

Inoue, E

Hanai, M

Yamada, K

Esashi, T

Yamauchi, J

机构：

[1] Natl Inst Hlth & Nutr, Div Appl Food Res, Shinjuku Ku, Tokyo 1628636, Japan

[2] Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan

[3] Seitoku Univ, Fac Humanities, Dept Human Life & Culture, Chiba 2718555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 10期

关键词：

coactivator; histone acetyltransferase; p300/CBP-associated factor (PCAF); estrogen receptor; ovariectomy;

D O I：

10.1271/bbb.68.2209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations.

引用

页码：2209 / 2211

页数：3

共 15 条

[1] AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer [J].