New iboga-type alkaloids from Ervatamia hainanensis

被引：23

作者：

Liu, Zhi-Wen ^{[1
,2
]}

Huang, Xiao-Jun ^{[1
,2
]}

Xiao, Han-Lin ^{[2
]}

Liu, Guo ^{[1
,2
]}

Zhang, Jian ^{[1
,2
]}

Shi, Lei ^{[2
]}

Jiang, Ren-Wang ^{[1
,2
]}

Zhang, Xiao-Qi ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituent, Guangzhou 510632, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 36期

基金：

中国国家自然科学基金;

关键词：

MONOTERPENOID INDOLE ALKALOIDS; ABSOLUTE-CONFIGURATION; VOACANGA ALKALOIDS; STEM BARK; DIFFERENTIATION; OFFICINALIS; CHINENSIS; INTERACTS; LEAVES;

D O I：

10.1039/c6ra00185h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Seven new iboga-type alkaloids (1-7) and six known ones (8-13) were obtained from Ervatamia hainanensis. Their structures with absolute configurations were determined by spectroscopic data, Mosher's method, single crystal X-ray diffraction and electric circular dichroism (ECD) analyses. The relationship between the absolute configuration of C-7 in iboga-type 7-hydroxyindolenine alkaloids and the Cotton effects in the ECD spectrum was established for the first time. The neural activities of these compounds were evaluated, and compound 11 exhibited protective effects against MPP+ (1-methyl-4-phenylpyridinium)-induced damage in primary cortical neurons.

引用

收藏

页码：30277 / 30284

页数：8

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