Efficient guanylation of Nα,Nω-difunctionalized polyamines at the secondary amino functions

被引：6

作者：

Athanassopoulos, CM ^{[1
]}

Garnelis, T ^{[1
]}

Pantazaka, E ^{[1
]}

Papaioannou, D ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, GR-26500 Patras, Greece

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 48期

关键词：

polyamines; kukoamine A analogs; guanylation; thiourea derivatives; Mukaiyama's reagent; protecting groups;

D O I：

10.1016/j.tetlet.2004.10.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of N-alpha,N-omega-ditritylated linear and aromatic polyamines and of polyamine conjugates of the alkaloid kukoamine A (KukA) type with N,N'-bis(tert-butoxycarbonyl)thiourea in the presence of Mukaiyama's reagent produced high yields of derivatives guanylated at the secondary amino functions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8815 / 8818

页数：4

共 36 条

[1]

Baker TJ, 1999, SYNTHESIS-STUTTGART, P1423

[2] Synthesis and anti-HIV activity of guanidinoglycosides [J].