A walk-through of the yeast mating pheromone response pathway

被引：128

作者：

Bardwell, L ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

来源：

PEPTIDES | 2004年 / 25卷 / 09期

关键词：

yeast mating pheromone; mitogen-activated protein kinase; signal transduction; Saccharomyces cerevisiae;

D O I：

10.1016/j.peptides.2003.10.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae responds to the presence of peptide mating pheromone in its surroundings is one of the best understood signaling pathways in eukaryotes, yet continues to generate new surprises and insights. In this review, we take a brief walk down the pathway, focusing on how the signal is transmitted from the cell-surface receptor-coupled G protein, via a MAP kinase cascade, to the nucleus. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1465 / 1476

页数：12

共 157 条

[1]

Activation loop phosphorylation and catalysis in protein kinases: Is there functional evidence for the autoinhibitor model? [J].

Adams, JA .

BIOCHEMISTRY, 2003, 42 (03) :601-607

[2]

Sst2 is a GTPase-activating protein for Gpa1:: Purification and characterization of a cognate RGS-Gα protein pair in yeast [J].

Apanovitch, DM ;

Slep, KC ;

Sigler, PB ;

Dohlman, HG .

BIOCHEMISTRY, 1998, 37 (14) :4815-4822

[3]

Ash J, 2003, GENETICS, V163, P9

[4]

A role for the yeast actin cytoskeleton in pheromone receptor clustering and signalling [J].

Ayscough, KR ;

Drubin, DG .

CURRENT BIOLOGY, 1998, 8 (16) :927-930

[5]

Cell surface polarization during yeast mating [J].

Bagnat, M ;

Simons, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14183-14188

[6]

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAR phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity [J].

Bardwell, AJ ;

Abdollahi, M ;

Bardwell, L .

BIOCHEMICAL JOURNAL, 2003, 370 (370) :1077-1085

[7]

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission [J].

Bardwell, AJ ;

Flatauer, LJ ;

Matsukuma, K ;

Thorner, J ;

Bardwell, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (13) :10374-10386

[8]

Differential regulation of transcription: Repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins [J].

Bardwell, L ;

Cook, JG ;

Zhu-Shimoni, JX ;

Voora, D ;

Thorner, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15400-15405

[9]

Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK [J].

Bardwell, L ;

Cook, JG ;

Voora, D ;

Baggott, DM ;

Martinez, AR ;

Thorner, J .

GENES & DEVELOPMENT, 1998, 12 (18) :2887-2898

[10]

SIGNAL PROPAGATION AND REGULATION IN THE MATING PHEROMONE RESPONSE PATHWAY OF THE YEAST SACCHAROMYCES-CEREVISIAE [J].

BARDWELL, L ;

COOK, JG ;

INOUYE, CJ ;

THORNER, J .

DEVELOPMENTAL BIOLOGY, 1994, 166 (02) :363-379

← 1 2 3 4 5 6 7 8 9 10 →