Spatial regulation of exocytosis and cell polarity: Yeast as a model for animal cells

被引：41

作者：

Brennwald, Patrick ^{[1
]}

Rossi, Guendalina ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 11期

关键词：

Rho GTPases; Lgl; exocytosis; cell polarity;

D O I：

10.1016/j.febslet.2007.03.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exocytosis is the major mechanism by which new membrane components are delivered to the cell surface. In most, if not all, eukaryotic cells this is also a highly spatially regulated process that is tightly coordinated with the overall polarity of a cell. The Rho/Cdc42 family of GTPases and the lethal giant larvae/Sro7 family are two highly conserved families of proteins which appear to have dual functions both in cell polarity and exocytosis. Analysis of their functions has begun to unravel the coordination between these processes and propose a model for polarized vesicle docking and fusion at the site of asymmetric cell growth. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2119 / 2124

页数：6

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