The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells

被引：35

作者：

Bartholin, Laurent

Wessner, Lisa L.

Chirgwin, John M.

Guise, Theresa A.

机构：

[1] Univ Virginia, Dept Internal Med, Div Endocrinol & Metab, Charlottesville, VA 22908 USA

[2] Ctr Leon Berard, INSERM, U590, F-69373 Lyon 08, France

来源：

CANCER LETTERS | 2007年 / 246卷 / 1-2期

关键词：

TGFbeta; CCN; Cyr61; CTGF; Smad; promoter;

D O I：

10.1016/j.canlet.2006.02.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyr61 is a multifunctional protein that can stimulate angiogenesis and tumor growth. Its expression by many cancers and breast cancers increases with tumor grade. Cyr61 is closely related to connective tissue growth factor, CTGF. Both proteins regulate skeletal development, suggesting that they could contribute to breast cancer metastases to bone, a process regulated by TGF beta. We show that Cyr61 transcription is activated by TGF beta and that the human Cyr61 promoter contains consensus sequences that bind Smad proteins. TGF beta in the tumor microenvironment may stimulate cancer metastases to sites such as bone by increasing Cyr61 expression and secretion. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：230 / 236

页数：7

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