The path to insulin resistance: Paved with ceramides?

被引：29

作者：

Zierath, Juleen R. ^{[1
]}

机构：

[1] Karolinska Inst, Dept Mol Med & Surg, Sect Integrat Physiol, S-17177 Stockholm, Sweden

来源：

CELL METABOLISM | 2007年 / 5卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2007.02.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor alpha, and glucocorticoids increase intracellular lipid metabolites and promote insulin resistance. In this issue, Holland et al. (2007) provide pharmacological and genetic evidence that ceramide plays a key role in the development of insulin resistance induced by these factors.

引用

页码：161 / 163

页数：3

共 10 条

[1]

DOBROWSKY RT, 1993, J BIOL CHEM, V268, P15523

[2] Ceramides and sphingomyelins in skeletal muscles of the rat:: content and composition.: Effect of prolonged exercise [J].

Dobrzyn, A ;

Górski, J .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 282 (02) :E277-E285

[3]

HANNUN YA, 1994, J BIOL CHEM, V269, P3125

[4] Inflammation and metabolic disorders [J].

Hotamisligil, Goekhan S. .

NATURE, 2006, 444 (7121) :860-867

[5] Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α [J].

Itani, SI ;

Ruderman, NB ;

Schmieder, F ;

Boden, G .

DIABETES, 2002, 51 (07) :2005-2011

[6] Signal transduction of stress via ceramide [J].

Mathias, S ;

Peña, LA ;

Kolesnick, RN .

BIOCHEMICAL JOURNAL, 1998, 335 :465-480

[7] Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes [J].

McGarry, JD .

DIABETES, 2002, 51 (01) :7-18

[8] Regulation of insulin action by ceramide - Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B [J].

Stratford, S ;

Hoehn, KL ;

Liu, F ;

Summers, SA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) :36608-36615

[9] A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome [J].

Summers, SA ;

Nelson, DH .

DIABETES, 2005, 54 (03) :591-602

[10]

TURINSKY J, 1990, J BIOL CHEM, V265, P16880

← 1 →