Ageing and the neutrophil: no appetite for killing?

被引：151

作者：

Butcher, S ^{[1
]}

Chahel, H ^{[1
]}

Lord, JM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, MRC, Ctr Immune Regulat,Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNOLOGY | 2000年 / 100卷 / 04期

关键词：

D O I：

10.1046/j.1365-2567.2000.00079.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the armoury of the immune system developed to combat the various micro-organisms that could invade the host, the neutrophil forms the first line of defence against rapidly dividing bacteria and fungi. However, as humans age they become more susceptible to infection with these microbes and this has been ascribed to a decline in immune status, termed immune senescence. Here we summarize the literature specifically concerning the attenuation of neutrophil function with age and the possible mechanisms underlying their reduced response to infectious agents.

引用

页码：411 / 416

页数：6

共 45 条

[1] Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep [J].