On the mechanism of the antitumor activity of ferrocenium derivatives

被引：257

作者：

Osella, D

Ferrali, M

Zanello, P

Laschi, F

Fontani, M

Nervi, C

Cavigiolio, G

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci & Tecnol Avanzate, I-15100 Alessandria, Italy

[2] Univ Siena, Ist Patol Gen, I-53100 Siena, Italy

[3] Univ Siena, Dipartimento Chim, I-53100 Siena, Italy

[4] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

来源：

INORGANICA CHIMICA ACTA | 2000年 / 306卷 / 01期

关键词：

antitumor agents; free radicals; ferrocenium complexes;

D O I：

10.1016/S0020-1693(00)00147-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Contradictory results exist in the literature about the antineoplastic activity of ferrocenes and their ferrocenium salts; additionally, little is known about the mechanism by which such drugs become active towards cancer cells. In the present paper we show that only ferrocenium species are able to inhibit the growth of Ehrlich ascites tumor cells in vivo and we propose that the cytotoxic activity of ferrocenium salts is not based on their direct linking to DNA, but on their ability to generate oxygen active species which induce oxidative DNA damage. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：42 / 48

页数：7

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