Exercise versus recovery electrocardiography for predicting outcome in hypertensive patients with chest pain

被引:8
作者
Bigi, R
Cortigiani, L
Gregori, D
De Chiara, B
Parodi, O
Fiorentini, C
机构
[1] Osped Niguarda Ca Granda, Inst Clin Physiol, CNR, I-20162 Milan, Italy
[2] Campo Marte Hosp, Cardiovasc Unit, Lucca, Italy
[3] Univ Turin, Dept Publ Hlth & Microbiol, I-10124 Turin, Italy
[4] Univ Milan, Dept Cardiol, S Paolo Acad Hosp, I-20122 Milan, Italy
关键词
hypertension; chest pain; electrocardiography; coronary disease; prognosis;
D O I
10.1097/00004872-200411000-00023
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background Exercise electrocardiography has limited prognostic accuracy in hypertensives because of unsatisfactory specificity. We prospectively used comparative stress-recovery heart rate-adjusted ST (ST/HR) analysis to predict mortality in a consecutive population of hypertensives with chest pain. Methods The stress-recovery index (SRI), defined as the difference between ST/HR areas during exercise and recovery, was derived in 460 hypertensive with known (n = 360, 78%) or suspected (n = 100, 22%) coronary artery disease. To assess whether it added prognostic information to routinely obtained information, clinical data, the resting ejection fraction, and exercise testing data were entered into a sequential Cox's model; the SRI was entered last Model validation was performed by bootstrap adjusted by the degree of optimism in estimates. Survival analysis was performed using the product-limit Kaplan-Meier method. Results During a median follow-up of 28 months (interquartile range, 13-44 months), 32 (7%) patients died, 23 (5%) suffered from acute myocardial infarction and 60 (13%) underwent late (> 3 months) revascularization. Male gender (hazard ratio, 1.53; 95% confidence interval, 1.01-2.34), peak double product (hazard ratio, 0.70; 95% confidence interval, 0.54-0.90) and the SRI (hazard ratio, 0.69; 95% confidence interval, 0.59-0.81 for interquartile difference) were independent predictors of outcome. The SRI increased the prognostic power of the model on top of clinical and exercise testing variables (concordance index, + 10%; discrimination index, + 32%) and showed the widest area under the ROC curve to predict outcome as compared with exercise-only ST analysis and the ST/HR index. Moreover, it provided a significant discrimination of survival. Conclusions The SRI predicts all-cause mortality in hypertensive patients with chest pain and provides additional prognostic information over clinical and standard exercise testing data. (C) 2004 Lippincott Williams Wilkins.
引用
收藏
页码:2193 / 2199
页数:7
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