Radiation-induced damage to cellular DNA: measurement and biological role

被引：46

作者：

Cadet, J ^{[1
]}

Douki, T ^{[1
]}

Gasparutto, D ^{[1
]}

Ravanat, JL ^{[1
]}

机构：

[1] CEA, SCIB, DRFMC, Lab Les Acides Nucl, F-38054 Grenoble 9, France

来源：

RADIATION PHYSICS AND CHEMISTRY | 2005年 / 72卷 / 2-3期

关键词：

ionizing radiation; base lesions; *OH radical; one-electron oxidation; cyclonucleosides; oxidized guanine; tandem lesion; DNA repair; oligonucleotide synthesis; mutagenesis;

D O I：

10.1016/j.radphyschem.2003.12.059

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Emphasis is placed in this short review on recent developments concerning several aspects of the chemical and biochemical effects of ionizing radiation on both isolated and cellular DNA. This includes the mechanism of formation of single and tandem DNA lesions upon one-electron oxidation and one hydroxyl radical hit only. Information is also provided on the specificity of DNA repair enzymes and the measurement of radiation-induced damage in cellular DNA. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：293 / 299

页数：7

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