Dynamic susceptibility contrast MRI of gliomas

Angiogenesis is gaining in interest as several antiangiogenic drugs for cancer treatment are in clinical trials. At the same time, the importance of imaging the angiogenesis has grown, since it may help to identify the patient material optimal for therapy, monitor the effect of treatment and detect failures as early as possible. Dynamic susceptibility contrast MRI is able to describe several aspects of normal and diseased microvascular system. In recent years, dynamic susceptibility MRI has been the target of intense research, and the information content it can provide has increased and is increasing dramatically. This article describes the dynamic susceptibility contrast MRI technique and its applications in the characterization of gliomas.