Modeling network dynamics:: the lac operon, a case study

被引：151

作者：

Vilar, JMG

Guet, CC

Leibler, S

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 161卷 / 03期

关键词：

gene expression; induction; lac operon; computational modeling; regulation;

D O I：

10.1083/jcb.200301125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

引用

收藏

页码：471 / 476

页数：6

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