Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis

被引：90

作者：

Peng, Xiao-dong ^{[1
,2
,3
]}

Dai, Li-li ^{[4
]}

Huang, Chang-quan ^{[1
,2
]}

He, Chun-mei ^{[1
,2
]}

Yang, Bing ^{[1
,2
]}

Chen, Li-juan ^{[1
,2
]}

机构：

[1] Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, W China Med Sch, W China Hosp, Ctr Canc, Chengdu 610041, Sichuan, Peoples R China

[3] N Sichuan Med Coll, Affiliated Hosp, Dept Oncol, Nanchong 637000, Sichuan, Peoples R China

[4] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Chongqing 400010, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 388卷 / 01期

关键词：

Panax notoginseng saponins; Liver fibrosis; Hepatic stellate cells; Cytokines; CARBON-TETRACHLORIDE; LIVER FIBROSIS; HEPATOTOXICITY; EXPRESSION; CELLS;

D O I：

10.1016/j.bbrc.2009.07.099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The aim of this study was to investigate the relationship between anti-fibrotic effect of Panax notoginseng saponins (PNS) and serum cytokines in rat hepatic fibrosis. Hepatic fibrosis induced by carbon tetrachloride (CCl4) was studied in animal models using SD rats. Liver index, serum alanine amino transferase (ALT), aspartate amino transferase (AST), transforming growth factor-beta 1 (TGF-beta 1), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured, respectively. Liver index and the degree of liver fibrosis were also determined. Our results showed that the levels of ALT, AST and liver index in PNS-treated group were markedly lower than those in model group. PNS therapy also significantly attenuated the degree of hepatic fibrosis, collagen area and collagen area percent in liver tissue. Furthermore, the levels of serum TGF-beta 1, TNF-alpha and IL-6 were strikingly reduced in PNS-treated group compared with model group while the production of IL-10 was up-regulated. These findings demonstrate that PNS has certain therapeutic effects on hepatic fibrosis probably by immunoregulating the imbalance between pro-fibrotic and anti-fibrotic cytokines. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：31 / 34

页数：4

共 17 条

[1]

Pathogenesis of liver fibrosis [J].