Design of nanocapsules based on novel fluorophilic cyclodextrin derivatives and their potential role in oxygen delivery

被引：18

作者：

Skiba, M ^{[1
]}

Skiba-Lahiani, M ^{[1
]}

Arnaud, P ^{[1
]}

机构：

[1] UFR Med & Pharm, Pharm Galen Lab, F-76000 Rouen, France

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2002年 / 44卷 / 1-4期

关键词：

nanocapsules; oxygen carriers; perfluorinated-cyclodextrin; perfluorodecalin;

D O I：

10.1023/A:1023090528809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The authors report an amphiphilic and fluorophilic beta-cyclodextrin derivative synthesized (perfluoro-beta-cyclodextrins: beta-CD-C-8(F)) according to a patent registered by Skiba et al. A new type of nanocapsule (PFC-NC) based on perfluoro-beta-cyclodextrins was prepared in a single step by colloidal nanoprecipitation. PFC-NC is fluorophilic carrier that could potentially be used in various types of pharmaceutical posology. Their potential as controlled release oxygen delivery systems was evaluated. PFC-NC were spherical and homogeneous particles with mean diameter of 335 nm and zeta potential of -73 mV. They were stable for 35 days at 4 and 25degreesC. PFC-NC have a prolonged delivery of oxygen with a delayed release as compared to water. The results of this study suggests that highly fluorinated-cyclodextrin could constitute a promising new component of nanocapsules. Fluorocarbon-in-water nanocapsules also represent a safe and cost-effective vehicles for in-vivo oxygen delivery.

引用

页码：151 / 154

页数：4

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