Multivitamin use and risk of prostate cancer in the national institutes of health-AARP diet and health study

被引：137

作者：

Lawson, Karla A.

Wright, Margaret E.

Subar, Amy

Mouw, Traci

Hollenbeck, Albert

Schatzkin, Arthur

Leitzmann, Michael F.

机构：

[1] Division of Cancer Prevention, Bethesda, MD

[2] Cancer Epidemiology and Genetics, Bethesda, MD

[3] Cancer Control and Population Sciences, Bethesda, MD

[4] National Cancer Institute, Bethesda, MD

[5] AACR, Washington, DC

[6] Rockville, MD 20852-7232

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2007年 / 99卷 / 10期

关键词：

D O I：

10.1093/jnci/djk177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Multivitamin supplements are used by millions of Americans because of their potential health benefits, but the relationship between multivitamin use and prostate cancer is unclear. Methods: We prospectively investigated the association between multivitamin use and risk of prostate cancer (localized, advanced, and fatal) in 295344 men enrolled in the National Institutes of Health (NIH)-AARP Diet and Health Study who were cancer free at enrollment in 1995 and 1996. During 5 years of follow-up, 10241 participants were diagnosed with incident prostate cancer, including 8765 localized and 1476 advanced cancers. In a separate mortality analysis with 6 years of follow-up, 179 cases of fatal prostate cancer were ascertained. Multivitamin use was assessed at baseline as part of a self-administered, mailed food-frequency questionnaire. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated by use of Cox proportional hazards regression, adjusted for established or suspected prostate cancer risk factors. Results: No association was observed between multivitamin use and risk of localized prostate cancer. However, we found an increased risk of advanced and fatal prostate cancers (RR = 1.32, 95% CI = 1.04 to 1.67 and RR = 1.98, 95% CI = 1.07 to 3.66, respectively) among men reporting excessive use of multivitamins (more than seven times per week) when compared with never users. The incidence rates per 100000 person-years for advanced and fatal prostate cancers for those who took a multivitamin more than seven times per week were 143.8 and 18.9, respectively, compared with 113.4 and 11.4 in never users. The positive associations with excessive multivitamin use were strongest in men with a family history of prostate cancer or who took individual micronutrient supplements, including selenium, β-carotene, or zinc. Conclusion: These results suggest that regular multivitamin use is not associated with the risk of early or localized prostate cancer. The possibility that men taking high levels of multivitamins along with other supplements have increased risk of advanced and fatal prostate cancers is of concern and merits further evaluation. The Author 2007. Published by Oxford University Press.

引用

页码：754 / 764

页数：11

共 39 条

[1]

Radimer K., Bindewald B., Hughes J., Ervin B., Swanson C., Picciano M.F., Dietary supplement use by US adults: Data from the National Health and Nutrition Examination Survey, 1999-2000, Am J Epidemiol, 160, pp. 339-349, (2004)

[2]

Blendon R.J., DesRoches C.M., Benson J.M., Brodie M., Altman D.E., Americans' views on the use and regulation of dietary supplements, Arch Intern Med, 161, pp. 805-810, (2001)

[3]

Muntwyler J., Hennekens C.H., Manson J.E., Buring J.E., Gaziano J.M., Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality, Arch Intern Med, 162, pp. 1472-1476, (2002)

[4]

Lee I.M., Antioxidant vitamins in the prevention of cancer, Proc Assoc Am Physicians, 111, pp. 10-15, (1999)

[5]

Jemal A., Siegel R., Ward E., Murray T., Xu J., Smigal C., Et al., Cancer statistics, CA Cancer J Clin, 56, pp. 106-130, (2006)

[6]

Patterson R.E., White E., Kristal A.P., Neuhouser M.L., Potter J.D., Vitamin supplements and cancer risk: The epidemiologic evidence, Cancer Causes Control, 8, pp. 786-802, (1997)

[7]

Kristal A.R., Stanford J.L., Cohen J.H., Wicklund K., Patterson R.E., Vitamin and mineral supplement use is associated with reduced risk of prostate cancer, Cancer Epidemiol Biomarkers Prev, 8, pp. 887-892, (1999)

[8]

Watkins M.L., Erickson J.D., Thun M.J., Mulinare J., Heath Jr. C.W., Multivitamin use and mortality in a large prospective study, Am J Epidemiol, 152, pp. 149-162, (2000)

[9]

Meyer F., Galan P., Douville P., Bairati I., Kegle P., Bertrais S., Et al., Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial, Int J Cancer, 116, pp. 182-186, (2005)

[10]

Stevens V.L., McCullough M.L., Diver W.R., Rodriguez C., Jacobs E.J., Thun M.J., Et al., Use of multivitamin and prostate cancer mortality in a large cohort of US men, Cancer Causes Control, 16, pp. 643-650, (2005)

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