Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

被引：116

作者：

Asanuma, K

Ma, Y

Okulski, J

Dhawan, V

Chaly, T

Carbon, M

Bressman, SB

Eidelberg, D

机构：

[1] N Shore Long Isl Jewish Res Inst, Ctr Neurosci, Manhasset, NY 11030 USA

[2] N Shore Univ Hosp, Dept Neurol, New York, NY USA

[3] NYU, Sch Med, New York, NY USA

[4] Beth Israel Med Ctr, Dept Neurol, New York, NY 10003 USA

来源：

NEUROLOGY | 2005年 / 64卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000149764.34953.BF

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine whether reduced striatal D-2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [C-11]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D-2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D-2 binding reductions are a trait feature of the DYT1 genotype.

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页码：347 / 349

页数：3

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