HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB10701,DQA10201 haplotype

被引：29

作者：

Lavard, L

Madsen, HO

Perrild, H

Jacobsen, BB

Svejgaard, A

机构：

[1] Natl Univ Hosp, Dept Clin Immunol, DK-2200 Copenhagen N, Denmark

[2] Glostrup Univ Hosp, Dept Paediat, Copenhagen, Denmark

[3] Odense Univ Hosp, Dept Paediat, Odense, Denmark

[4] Bispebjerg Hosp, Dept Internal Med, Copenhagen, Denmark

来源：

TISSUE ANTIGENS | 1997年 / 50卷 / 06期

关键词：

juvenile Graves' disease; HLA disease association; protective HLA type;

D O I：

10.1111/j.1399-0039.1997.tb02922.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies have shown that HLA-DRB1*0301 and DQA1*0501 are associated with susceptibility to Graves' disease. Ninety Danish patients with early onset of Graves' disease and 102-192 controls were analyzed for HLA-DR and -DQ to investigate if the same associations exist in the juvenile form of Graves' disease. Both DRB1*0301 and DQA1*0501 were highly significantly increased in the patients with relative risks of 8.0 and 4.6, which are higher than those seen in adults. Stratification showed that DRB1*0301 is more strongly associated than DQA1*0501. Surprisingly, the DRB1*0701,DQA1*0201 haplotype was completely absent from this group of patients, indicating a strong protective role of this haplotype in juvenile Graves' disease.

引用

页码：639 / 641

页数：3

共 12 条

[1] TUMOR NECROSIS FACTOR-BETA GENE POLYMORPHISMS IN GRAVES-DISEASE [J].