The first highly enantioselective homogeneously catalyzed asymmetric reductive amination:: Synthesis of α-N-benzylamino acids

被引：109

作者：

Kadyrov, R

Riermeier, TH

Dingerdissen, U

Tararov, V

Börner, A

机构：

[1] Degussa AG, Project House Catalysis, D-65926 Frankfurt, Germany

[2] Univ Rostock, Leibniz Inst Organ Katalyse, D-18055 Rostock, Germany

[3] Univ Rostock, Fachbereich Chem, D-18049 Rostock, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 10期

关键词：

D O I：

10.1021/jo020690k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High-throughput screening considering a library of 96 chiral P-ligands involved in two types of Rh-I complexes was used for the identification of homogeneous catalysts for the highly enantioselective reductive amination of a-keto acids with benzylamine. After optimization of the reaction conditions and scale-up with a cationic Rh-Deguphos catalyst, a range of chiral alpha-amino acids could be produced by this new reaction in good yield and by up to 98% ee.

引用

页码：4067 / 4070

页数：4

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